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Sun X, Yi C, Zhu Y, Ding L, Xia S, Chen X, et al

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1 Introduction Cancer fundamentally stems from the disruption of normal cellular growth and division, highlighting the necessity for effective therapeutic strategies to address this disease ( Chemotherapeutic agents used for cancer treatment are either developed from antibiotics or chemically synthesized ( Doxorubicin (DXN) is a widely used chemotherapeutic agent, which is antibiotic, belonging to the anthracycline group, is produced by Streptomyces peucetius and is effective in treating breast and ovarian cancers, soft tissue and bone sarcomas, thyroid cancers, and bladder cancers ( Glucagon-Like Peptide-1 (GLP-1) is a hormone integral to the regulation of insulin and glucose metabolism, and it is utilized in the treatment of type 2 diabetes and obesity ( Glucagon-like peptide-1 receptors (GLP-1Rs) are located in the hippocampus, dorsomedian, paraventricular, and arcuate regions of the brain ( Despite the fact that chemobrain is frequently observed in breast cancer patients and DXN is a widely administered anticancer in their treatment protocols, there is a significant gap in research concerning the protective effects of tirzepatide on DXN-induced memory impairments in female rats, as well as the exploration of potential intervention methods

(PubMed) Dunham RM, Gordon SN, Vaccari M, et al