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Axford at I24, Diamond Light Source, Oxford, UK for technical support

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In fact, studies have shown that every pound of weight loss can reduce knee joint load by roughly four pounds during movement

Preclinical studies showed that weight loss was driven by both reduced caloric intake and increased metabolic expenditure

The delayed gastric emptying from GLP-1 therapy amplifies the importance of these rules, as slower transit time increases the window during which stomach acid and other substances can interfere with thyroid hormone uptake

While laxatives for GLP-1 constipation can provide relief, they should ideally be used as a temporary measure alongside dietary and lifestyle modifications for long-term bowel regularity on GLP-1