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doi: 10.1089/thy.2010.1634 130 Rotondo DottoreGIonniIMenconiFCasiniGSellari-FranceschiniSNardiMet al

Clinical and behavioural assessment All enrolled participants underwent multidisciplinary evaluations, including neurological, diagnostic, cognitive, and behavioral assessments

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Each targets a different aging pathway

In the mouse model of bleomycin-induced lung fibrosis, Gpx3 levels in tissue and BALF were increased in the inflammatory (day 37) and fibrotic (day 1428) phase 35,46 , but had returned to baseline after resolution of fibrosis at day 56

The equivalent arginine-serine network in Rattus norvegicus OAT1 has been implicated in gating dynamics and the allosteric modulation of OAT1 by chloride 25 , with chloride binding to R466 rOAT1 in the inward-facing conformation stabilising this network