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Functional significance of cell volume regulatory mechanisms

Protein misfolding and failure of clearance systems, including the autophagy-lysosome and ubiquitin-proteasome pathways, further compromise the cellular environment and lead to toxic intracellular accumulations [31, 32]

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It acts primarily as an enzyme inhibitor (notably of CYP enzymes and UGT-mediated glucuronidation), which can increase plasma concentrations of co-administered drugs

Targeting myocardial substrate metabolism in heart failure: potential for new therapies

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