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Silica NPs could induce oxidative stress, inflammation, and NO/NOS system disorder, ultimately causing endothelial cytotoxicity by activating the MAPK/Nrf2 and NF-B signaling pathways ( 2 NPs induced the lung alveolar epithelial cell apoptosis by ROS-regulated PI3K/AKT-mediated mitochondria- and ER stress-dependent signaling pathways, leading to lung injury (Lee et al., 2020)

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The dual role of astrocytes in AD emphasizes the importance of understanding their transformation and interactions within the brains pathological landscape

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