Age-Related Decline In the body, GHK-Cu naturally occurs at concentrations of approximately 200 ng/mL in plasma at age 20, but these levels decline progressively with age to less than 80 ng/mL by age 60 - this age-related decline correlates with decreased tissue repair capacity, skin aging, and impaired regenerative responses, leading to the hypothesis that GHK-Cu decline contributes to aging phenotypes and that restoration of youthful levels through supplementation could have anti-aging benefits
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Koonen DP, Jacobs RL, Febbraio M, Young ME, Soltys CL, Ong H, Vance DE, Dyck JR (2007) Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity
As with doxorubicin, cisplatin treatment also results in ROS generation, which is neutralised by the NADPH-powered glutathione system, warranting investigation of this strategy for other forms of chemotherapy which are detoxified via this system