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The entire process is incredibly fast

Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6

Stability and delivery are still issues for peptide therapy

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In skin of colour, post-inflammatory pigmentation in these areas can be persistent and distressing

At the same time, multivalent and multi-specific nanobodies were constructed to improve their affinity and specificity 12