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Normal serum bicarbonate: 2228 mmol/L Physiological Role Maintains blood pH (~7.357.45) Buffers metabolic acids Works with lungs and kidneys in acidbase regulation Buffer equation: CO + HO HCO H + HCO Regulation Lungs Control CO (acid component) via ventilation Kidneys Reabsorb filtered bicarbonate Generate new bicarbonate Excrete hydrogen ions (H) Clinical Uses of Bicarbonate (Sodium Bicarbonate) Indications 1

This distinguishes the pen from any licensed pharmaceutical product dispensed through a UK pharmacy: there is no Marketing Authorisation, no SmPC (Summary of Product Characteristics), and no patient information leaflet

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4), S7479 (2000), doi:10.1038/sj.ijir.3900582

doi: 10.1002/jmv.24810 131 LernerAMArizaMEWilliamsMJasonLBeqajSFitzgeraldJTet al

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