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Some patients report changes within weeks, while others experience more gradual improvements over time

In a recent study in liver cirrhosis of any cause, not only urinary 51 Cr-EDTA excretion was elevated in about half the patients and associated with Child-Pugh state, it was also present in all ascites samples from patients with spontaneous bacterial peritonitis (SBP) (143)

None of these routes has been characterized in published human pharmacokinetic studies

Both have been used in research and clinical practice