therefore, TLR-mediated inflammation can be reduced by inhibiting MYD88 palmitoylation or by limiting endogenous palmitate available for protein modification ( 3.2 NOD1/2 pathway NOD1 and NOD2, two well-characterized pattern recognition receptors (PRRs) in the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family, sense bacterial peptidoglycan (PGN) and activate intracellular signaling pathways that drive pro-inflammatory and antibacterial responses ( Membrane localization of NOD1/2 is essential for its mediated immune signaling
10.1016/j.cell.2017.06.030 Cell 9 ChatterjeeT.MuhkopadhyayA.KhanK
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