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IL-10, an anti-inflammatory cytokine, increases

This is unfortunate, as studies have found that poor sleep is itself a form of stress and can lead to decreases in glutathione levels and oxidative damage

Proinflammatory cytokines TNF- and IL1- activate the canonical NF-B pathway that induce the gene expression of cyclooxigenase-2, inducible nitric oxide synthase-3, inflammatory cytokines, and matrix metalloproteinases [75] These changes lead to the damage of TJs, decreased endothelial integrity and increased permeability at the BBB [73, 76], and to neuroinflammation and the development of chronic neurodegenerative diseases such as AD [10, 77]

While these peptides show strong potential in preclinical and animal studies, particularly for certain disease model they are not FDA-approved drugs and should only be used for research or educational purposes

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