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In general, although topical treatment would be promising in melasma management, however, most of the available conventional topical formulations are challenging due to the limited skin permeability, low water solubility, low dermal bioavailability, and therefore insufficient clinical response

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however, it should still be handled and stored carefully and appropriately in line with laboratory standards

The enzymatic reaction was initiated by adding 1 mL of GPx enzyme solution (3000 units/liter) to 9 mL of a mixture containing potential interfering substances

Other DPP-4 Inhibitors Three more inhibitors were developed at the time and went through development: saxagliptin [a cyanopyrrolidide compound