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By identifying the gut microbiome as an active player in the effects mediated by GLP-1 instead of a mere passive factor, this review puts forth a conceptual framework designed to clarify the variability in therapeutic responses and to inform the creation of personalized GLP-1 strategies that take the microbiome into account

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This reveals which subpopulations in new indications are most likely to be responsive to GLP-1s and which are not, and which have the highest likelihood of specific adverse events

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