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In two analyses of spontaneous reports from the US Food and Drug Administrations adverse event reporting system database, the reporting rates of thyroid cancer were 4.7 and 8 times higher, respectively, for GLP1 receptor agonists compared with other diabetes drugs.23 In a meta-analysis based on 15 clinical trials that included at least one thyroid cancer outcome event, the odds ratio for thyroid cancer associated with GLP1 receptor agonists was 1.49 (95% confidence interval 0.83 to 2.66)

Singh MR, Saraf S, Vyas A, Jain V, Singh D

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These data indicate that the pharmacokinetics of cagrilintide are unaffected by renal impairment

RCTs are in progress looking at possible benefits for alcohol or nicotine addiction