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DISCUSSION The goal of this study was to develop an AnglV-derived molecule that retained the pro-cognitive/anti-dementia activity of AnglV and Nle'-AnglV but possessed improved pharmacokinetic properties, thus allowing it to penetrate the BBB in sufficient quantities to reach therapeutic levels in the brain

5-Amino-1MQ is studied for its relationship to NNMT pathway activity, a pathway of interest in metabolic research models involving adipocyte biology, NAD+-adjacent metabolism, methylation-related signaling, and cellular energy regulation