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Several laboratory studies have reported that UA has pro-inflammatory properties, including triggering the Akt/PRAS40 pathway, inducing IL-1 release, promoting ROS generation, and activating the toll-like receptor (TLR) 2/4 and NF-B signaling [48, 49]

Moreover, SCFAs might induce thermogenesis in brown adipose tissue (BAT), through upregulating mitochondrial uncoupling protein-1 (UCP-1), and white adipose tissue (WAT) browning (37, 58)

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Compounded medications are not FDA-approved and may be prescribed only when a licensed prescriber determines a clinically significant difference for an identified patient

E., No, J., Lee, K., & Shin, M

Orfoglipron: A Comprehensive Review of an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity and Type 2 Diabetes