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These mice were separated into four groups [Figure 1] as follows: Group 1: Control group ( n = 7): Mice had received 0.5 ml of distilled water orally for ten consistent days, and on the 10 th day, sodium chloride was injected intraperitoneally Group 2: MTX group ( n = 7): Mice had received 0.5 ml of distilled water orally for ten consistent days, and on the 10 th day, MTX was injected intraperitoneally in a dose of 20 mg/kg Group 3: Group PG150 ( n = 7): Mice had received 150 mg/kg of pomegranate orally for ten consistent days, and on the 10 th day, MTX was injected intraperitoneally in a dose of 20 mg/kg Group 4: Group PG300 ( n = 7): Mice had received 300 mg/kg of pomegranate orally for ten consistent days, and on the 10 th day, MTX was injected intraperitoneally in a dose of 20 mg/kg
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Notably, they exhibited lesser interstitial edema (only mild), markedly less damaged neurons than corresponding controls and had no inflammatory reaction ( Table 8 )
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