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Dimerization at some of these sites mitigates many of the redox dependent functions of the protein

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4.1 Molecular pathways governing ferroptosis cell death Iron is a critical driver of lipid peroxidation and subsequent ferroptosis within cellular environments (60, 61)

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19,84 Hepatocyte-specific SIRT1 knockout mice display liver steatosis, triglyceride accumulation, and increased de novo lipogenesis, even under standard dietary conditions, accompanied by SREBP-1c activation and impaired PGC-1/peroxisome proliferator-activated receptor alpha (PPAR) signaling