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Conversely, excessive lipid droplet accumulation within astrocytes and microglia is frequently associated with activation of pro-inflammatory transcriptional programs and release of neurotoxic mediators, thereby contributing to neuronal dysfunction and injury (Ralhan et al., 2021)
C., Garrett, T
FOXO3a acetylation regulates PINK1, mitophagy, inflammasome activation in murine palmitate-conditioned and diabetic macrophages
Eli Lilly, the pharmaceutical company behind retatrutide, declined to comment on the protocols of its ongoing trials but stated that patient safety is a priority
Abbreviations CQ: Chloroquine CSCs: Cancer stem cells ER: Estrogen receptor-alpha GPxs: Glutathione peroxidases GSH: Glutathione HCC: Hepatocellular carcinoma hiPSC-MSCs: Mesenchymal stem cells drived from human induced pluripotent stem cells IBC: Inflammatory breast cancer IH: Isorhamnetin LOH: Loss of heterozygosity MnSOD: Manganese superoxide dismutase NAC: N -acetylcysteine PHGPx: Phospholipid GPx ROS: Reactive oxygen species TNBC: Triple-negative breast cancer TFAP2C: Transcription factor AP-2 gamma References Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A
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