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"I have concerns about reducing access to really valuable clinical interventions," Fendrick said.

But anyone reading that headline needs to know what's underneath it because the foundational science behind dihexa comes with a $4 million False Claims Act settlement

Identified cellular targets through which PKA activation produces a bronchodilator effect include: MLCK: Phosphorylation of myosin light chain kinase (MLCK) by cAMP-dependent protein kinase (PKA) decreases the affinity of the kinase for Ca2+ and calmodulin , resulting in a decrease in MLCK activity

Volpe S, Lisco G, Fanelli M, Racaniello D, Colaianni V, Lavarra V, et al