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Methylmalonic acid in serum from patients with neurological symptoms consistent with cobalamin deficiency

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The compound showed an in vitro NNMT IC 50 of approximately 1.2 M and did not inhibit related methyltransferases at concentrations tested

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This transporter regulates foreign-agent pharmacokinetics in the brain by inhibiting or augmenting their movement across the BBB, which restrains morphine entry into the brain (Tournier et al., 2011)