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The original 2015 Cell Metabolism study demonstrated that intraperitoneal MOTS-c injections (5 mg/kg) in mice fed a high-fat diet prevented obesity and insulin resistance, with effects on fat mass, fasting glucose, and insulin sensitivity that rivaled pharmaceutical intervention [1]

Giunchi, V., Fusaroli, M., Hauben, M., Raschi, E

It informs our world view

When we support digestive health with compounds like berberine, we're essentially optimizing the body's primary toxin elimination highway." What Are the Specific Mechanisms of Berberine Supplement Action

Prices are now under $500/month for FDA-approved options (and I strongly recommend avoiding compounds)

At the 15 mg dose, 91% achieved at least 5% weight loss and 57% achieved at least 20%