However, some weight regain does happen naturally as metabolism decreases with age
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Adipose tissue insulin resistance is implicated in the pathogenesis of metabolic abnormalities in MASLD, leading to hepatic lipid accumulation and disordered glucose homeostasis [58]
A recent study published in JAMA Network Open has drawn attention to a possible, though rare, side effect: optic nerve disorders , specifically a condition known as non-arteritic anterior ischemic optic neuropathy (NAION)
Tirzepatide's shorter half-life creates larger peak-to-trough fluctuations, making split dosing potentially more impactful for that medication
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