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Results Primary Cohort After applying the inclusion and exclusion criteria, we identified 413 patients in the main cohort who achieved HbA1c 300 mg/g decreased from 6.5% at baseline to 4.1% in the 1st year and 5.5% in the 2nd year (shown in Supplementary Fig

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This theoretically preserves the cytosolic pool of NAD+ (Nicotinamide Adenine Dinucleotide), which is critical for sirtuin activation and mitochondrial oxidative phosphorylation

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