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Therapeutic effects of short cyclic and combined epitope peptides in a long-term model of Graves disease and orbitopathy

Blood sugar stabilization Chronically elevated blood sugar, even at levels that do not meet the diagnostic threshold for diabetes, causes persistent low-grade fatigue

Breakthrough bleeding can occur as cycles recalibrate

Mechanisms Beyond Adiposity: The substantial MACE reduction not explained by weight or waist changes points to direct cardiovascular effects, including: Improved endothelial function and vascular health Anti-inflammatory pathways via central GLP-1 receptor signalling Favourable effects on blood pressure and lipid metabolism Possible early adipose tissue metabolic improvements before measurable mass reduction 3

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The trajectory is steepening, not plateauing