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A positive test reproduces tingling in the median nerve distribution

Colour change (usually a darkening of the skin) can be a warning sign of melanoma

This severe metabolic inflexibility directly contributes to the debilitating phenomenon of post-exertional malaise (PEM), where patients experience a massive, multi-day crash in symptoms following minor physical or cognitive exertion, effectively trapping them in a cycle of energy debt

Vomiting: Less frequent than nausea but still notable, especially at higher doses

These hormones and the copycat GLP-1 medications act on the same circuit as two other crucial hormones, leptin and ghrelin, which tell us when were hungry and when were satiated