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The BoxBehnken design (BBD) and response surface modeling (RSM) were employed to determine the ideal conditions for the assay

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10.1016/j.chroma.2015.07.032 39

These effects are achieved through different mechanisms: 1) impairing of the ATP-gated P2X7 receptor (one on the main danger signal sensors on cells), that activates the NLPR3 inflammasome