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3-hydroxykynurenine is a ROS-inducing cytotoxic tryptophan metabolite that disrupts the TCA cycle

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These mitochondria are a primary source of ROS, making the kidneys especially susceptible to oxidative stress-related injury

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Reconstitute the solution in the powder vial with 100ml-500ml of Saline for injection by means of a syringe with an appropriate needle through IV Remove the seal of the vial and wipe closures with disinfectant, then insert the needle of the syringe in the vial through the center of the rubber closure and direct the flow of water toward the glass wall of the vial