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Mutations in TNSALP , whether autosomal recessive or dominant, result in different clinical presentations

Apart from improvements in multiple cardiometabolic risk factors, tirzepatide also improves various obesity-related complications such as obstructive sleep apnoea (OSA), metabolic dysfunction-associated steatohepatitis (MASH) and heart failure with preserved ejection fraction [28,29,30]

The nucleus tractus solitarii projects to multiple regions of the CNS involved in the regulation of appetite, including the hypothalamus, ventral tegmental area, lateral parabrachial nucleus, and nucleus accumbens (58, 59)

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Staying well-hydrated will also prevent any dehydration from vomiting or diarrhea