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Collectively, we conclude that -KG functions as an epigenetic cofactor to maintain TET-dependent DNA demethylation to facilitate YBX1 transcription, a prerequisite for AMPK translation

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Participants also tolerated the oral medication well, with mild to moderate gastrointestinal side effects

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In mouse studies, NNMT inhibition has been linked to reduced fat mass and improved metabolic markers in diet-induced obesity models (Neelakantan et al., 2018)