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Regulation in mRNA and protein levels and phosphorylation of many key molecules such as insulin receptor substrate (IRS), protein kinase B (PKB), phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt), Jun N-terminal Kinase 1 (JNK), MAPK, and fork-head box O family proteins (FOXO) involved in insulin signaling pathway were observed in diabetic animals treated with polysaccharides extracted from a number of mushrooms such as Grifola frondosa , L

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