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Reduction of fasting plasma glucose was comparable (3.35 mmol/L vs 3.21 mmol/L) after 26-week treatment with daily dose at 0.36 U/kg and 0.38 U/kg at week 26

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Overlapping substrates, serial reactions of nucleophilic addition, isomerization, and the stabilization of transitions states are common between the different GSTs [54,76]