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They cause oxidative stress

2012;2012 doi: 10.1155/2012/805762

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Significantly, SIRT1 is critical for controlling oxidative stress and mitochondrial metabolism

The proportion of participants achieving 20% or greater weight loss was 36% at the 10mg dose and 40% at the 15mg dose, results approaching what was previously achievable only with bariatric surgery

It improves sleep, skin health and appearance as an antioxidant, he said