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57 MMPs also play a role in vascular remodelling by modulating the migration and proliferation of smooth muscle cells and endothelial cells and mediating the release of the smooth muscle cell mitogens and growth factors, increasing the risk of COPD pulmonary hypertension

For example, the next generation of probiotics (NGP) has shown potential as disease-specific therapeutics and will help us understand the effectiveness and safety of probiotic microorganisms (127, 128)

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Switching to a lower maintenance dose, rather than stopping completely, is a common approach

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