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Research using MC4R knockout mice and selective MC4R antagonists has established MC4R as the primary receptor mediating MT-IIs pro-erectile and pro-sexual effects with MC4R-null mice showing substantially reduced or absent MT-II-induced erections and sexual behaviour, and MC4R-selective antagonists blocking these responses at doses not affecting MT-IIs melanogenic activity

Pekala, J., Patkowska-Sokoa, B., Bodkowski, R., Jamroz, D., Nowakowski, P., Lochyski, S., & Librowski, T

1 2Melanotan Tanning Injection: A Rare Cause of PriapismPMC / National Library of Medicine 2021

Daily use provides better results compared to irregular intake

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Hence, BioPerine helps your body better absorb and utilize the other active ingredients in LEAN Pre-Workout