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The 8 mg dose produced mean weight loss of approximately 22.8%, while the 4 mg dose achieved about 17.3% weight reduction

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These include weight gain, fluid retention, increased appetite, mood changes, elevated blood pressure, increased infection risk, osteoporosis, skin thinning, and metabolic disturbances including hyperglycaemia

The mechanism becomes especially concerning for semaglutide users who do not realize they need to dramatically increase their water intake to compensate for GI losses and suppressed thirst signals

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