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But during clinical trials, doctors noticed that GLP-1 medications also helped participants in the trial lose weight because it significantly reduced hunger

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A 2024 JAMA Internal Medicine trial led by Thomas Wadden found no clinically meaningful increase in depression or suicidal thoughts among semaglutide users and even a small reduction in depressive symptoms in people without prior psychopathology

It is frequently used to support exercise recovery and alleviate muscle soreness after intense training sessions