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Gln is metabolized by GLS to produce alpha-ketoglutaric acid (-KG), which serves as a crucial cofactor for TET enzymes that catalyze DNA demethylation, as well as for histone demethylases like JHDM

Given the implications of our study, further work in this area is likely to further illustrate the role of different parts of this system in maintaining a healthy balance between oxidative stress and antioxidants in neural tissue

& Selvarajah, D

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