Federici, S
Furthermore, gasdermins, which regulate inflammatory form of cell death, were upregulated in the brains of GCLC-KO mice, suggesting the contribution of pyroptosis to neuronal cell death in these animals
Its combination with gemcitabine can amplify the ICD effect of chemotherapy (Kajiwara et al., 2023), while reshaping the microenvironment (reducing M2 macrophages, recruiting NK cells) and overcoming DNA repair resistance mediated by RRM1 overexpression (such as triple-negative breast cancer models)
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For some, supplementing with glutathione or its precursors, like N-acetylcysteine (NAC), offers an extra boost
Dapagliflozin ameliorates renal tubular ferroptosis in diabetes via SLC40A1 stabilization