GSH can then be synthesized de novo in a two-step ATP-requiring enzymatic process utilizing glutamate cysteine ligase (GCL) and glutathione synthetase (GS) (Figure 2) [83,87]
Circu ML, Rodriguez C, Maloney R, Moyer MP, Aw TY
C 103, 109770
The AlkB family of Fe(II)/-ketoglutarate-dependent dioxygenases: repairing nucleic acid alkylation damage and beyond
Hydrogen attenuated inflammation response and oxidative in hypoxic ischemic encephalopathy via Nrf2 mediated the inhibition of NLRP3 and NF-B
More help Overall Assessment of the AOP Addressess the relevant biological domain of applicability (i.e., in terms of taxa, sex, life stage, etc.) and Weight of Evidence (WoE) for the overall AOP as a basis to consider appropriate regulatory application (e.g., priority setting, testing strategies or risk assessment)