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Under physiological conditions, mitochondria balance ROS production with antioxidant defenses (42)

Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels

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Unresolved renal inflammation could also trigger cell apoptosis and fibrosis by releasing pro-apoptotic, pro-fibrotic growth factors, cytokines, and chemokines ( Cell apoptosis and glomerular injuries are observed during renal ischemia

23: 3-25.CrossRef Pople JA, Gordon M