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Baseline estimated renal function was normal (eGFR 90 mL/min/1.73 m2) in 66.2%, mildly impaired (eGFR 60 to 90 mL/min/1.73 m2) in 32.4% and moderately impaired (eGFR 30 to 60 mL/min/1.73 m2) in 1.4% of patients

You notice bleeding, itching, or new irritation after a bowel movement

That's not really a side effect

The discomfort often correlates with meal timing and composition

TicinesiAMilaniCGuerraAAllegriFLauretaniFNouvenneAet alUnderstanding the gut-kidney axis in nephrolithiasis: an analysis of the gut microbiota composition and functionality of stone formers

A neutralizable epitope is induced on HGF upon its interaction with its receptor cMet