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19 Poor function of the stomach, pancreas, and small intestine (as is common in older adults) impairs vitamin B12 absorption, potentially leading to vitamin B12 deficiency

Kidney overload: High levels of vitamin B12 require the kidneys to work harder to eliminate it, which could lead to kidney stress and, in severe cases, kidney damage

But that doesnt mean they all stay in your system for the same amount of time

In human blood, hydroxo- and methylcobalamin are found in approximately equal proportions

(e) cross-sectional studies with no time restriction, (f) only studies published in English were included due to resource limitations and to ensure accuracy in data extraction and risk-of-bias assessment

Benefits include improvement in sleep, mood, energy levels, metabolism increase, hormone production, memory, skin, hair, teeth and nails