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a , b ) Total dopamine content in the striatum of Trkb Penk-KO decreases significantly by 89 months of age (43%) after the initial increase at around three months (DA, 3.5 M vs 89 M, p = 0.007)

4) spots were counted using the particle counting algorithm in Fiji with a size limit of 0.5-5 m, and roundness of 0.5-1

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