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4.1.2 ARF-BP1, PAM and FBXL3 ARF-BP1, also known as HUWE1 in Drosophila , and PAM, also known as highwire in Drosophila , are critical E3 ubiquitin ligases that regulate the stability of REV-ERB, a component of the circadian clock mentioned above that is responsible for repressing genes like BMAL1 (Yin et al., 2010)