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Clinical data from GLP-1 trials shows that 50% of participants see at least 5% body weight loss by week 6, marking a psychological turning point where progress becomes visible and motivating

More broadly, some reviews have suggested a conservative class-level washout approach of at least 4 weeks where direct evidence is lacking, although this should not replace molecule-specific label guidance (154)

If you're scheduled for surgery and currently taking semaglutide or another GLP-1 receptor agonist, your surgical team needs to know about your medication history

Any medication that sees this rapid adoption warrants close examination, particularly in orthopedics where obesity and surgical intervention often overlap, and when the long-term effects of GLP-1 RA exposure on bone and joint health remain poorly understood, Muaaz Wajahahth, a fourth-year medical student at Michigan State University College of Human Medicine, said

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