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Future research should prioritize the development of receptor-selective modulators with proven long-term efficacy, capitalizing on astrocyte-specific biology to optimize neuroprotective therapeutic outcomes

The scRNA-seq and bulk RNA-seq data underwent extensive bioinformatic processing, including dimensionality reduction (UMAP), cell-type clustering, identification of DEGs, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and pseudotime trajectory analysis to map cellular differentiation and pathological progression

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patients should seek urgent medical attention for severe persistent abdominal pain and discontinue treatment if pancreatitis is confirmed

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