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They are entirely safe when administered by a trained healthcare expert Do the injections hurt

7 The consequence of an endplate fracture is a possible defect healing which abrogates the function of the endplate for disc nutrition and thus promotes disc degeneration

The mean changes in height SDS from baseline in years 2 through 5 of treatment were + 0.4 (SD = 0.7), + 0.6 (SD = 0.7), + 0.8 (SD = 0.8), and + 0.7 (SD = 1.0), respectively

Because this effect is entirely glucose-dependent, insulin secretion decreases as plasma glucose approaches normal levels, providing a significant safety advantage over traditional secretagogues

Neutrophil necroptosis is triggered by ligation of adhesion molecules following GM-CSF priming