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Research shows retatrutide may produce even more significant weight loss than existing medications that act on one or two hormone receptors with some people losing about 28% of their body weight over two years, according to early trial data

For most goals, this range represents the best balance of effectiveness and tolerability

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Given the well-documented benefits of behavior change interventions, including lifestyle and diet interventions, we recommend that these should always be offered and continued wherever metformin is offered