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Advances in nutrition (Bethesda, Md.), 6(5), 552563

In addition, the US Food and Drug Administration has not evaluated these statements

Conclusion Whilst severe B12 deficiency has a clear clinical picture with characteristic haematological and/or neurological features, establishing mild or borderline deficiency can be problematic as serum levels are maintained at the expense of tissue concentrations, and therefore serum levels of B12 may be in the low normal or borderline range despite a deficiency

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Constipation: A few users of vitamin B-complex supplements complain of constipation